Jae Seo Lee
Kyung Hee University, Republic of Korea
Title: Dual Stimuli-Responsive Degradable Quantum Dot-based Theranostic Agents targeting Breast Cancer
Biography
Biography: Jae Seo Lee
Abstract
Graphene Quantum Dots (GQD) have been widely used for theragnosis for cancer disease. However, one of the current challenges is considerably difficult to release therapeutic agent to target site. In this study, we modified GQD that introduced herceptin through polyethylene glycol (PEG) and disulfide bond to induce active targeting for specific cells and control the drug release. The resulting of UV spectroscopy, Fluorescence, Fourier Transform Infrared showed that GQD-complex (GQD-comp) was conjugated successfully. The cell viability was presented that GQD-comp had a substantial effect on HER2-overexpressing breast cancer cells. In endosomal condition of low pH and high glutathione, doxorubicin was rapidly released from Doxorubicin loaded GQD-comp. Besides, this optical imaging by confocal laser scanning microscopy indicated to certainly confirm intracellular trafficking. In conclusion, GQD-comp had potential theragnostic agents to HER2-positive breast cancer cells.