Marketa Benkova
University of Defence, Czech Republic
Title: Synthesis, antimicrobial efficacy and structure-activity relationships of three series of N-alkylammonium salts
Biography
Biography: Marketa Benkova
Abstract
Three series of N-alkylammonium salts (7a-c, 8a-b, 9a-b) based on quaternary ammonium compounds with a different length and type of carbon chain (C12, C14, C16) were synthesized, characterized (EA, HRMS, NMR) and tested in vitro for antimicrobial (antibacterial, antifungal and antialgal) activity. Furthermore, the critical micelle concentration (CMC), capacity factors k and cytotoxicity were likewise measured to elucidate possible structure-activity relationships. The antimicrobial activity of the prepared compounds has been evaluated and compared. All compounds being tested proved high efficacy against both Gram-positive and Gram-negative bacterial strains, excluding the activity against multi-resistant Pseudomonas aeruginosa. Antifungal testing showed high activity of most compounds against fungal strains (yeasts and filamentous fungi) except of Aspergillus niger. The relationship between length of carbon chain and the efficiency has been observed. Series 7a-c proved high antialgal efficacy. Cell viability assay confirmed an expected trend that increasing carbon chain length results in higher cytotoxicity.